ACKNOWLEDGMENTS I would like to sincerely thank my research advisor, Professor David H. Russell for his advice, guidance, direction and endless enthusiam for the subject of photoinduced proton transfer and MALDI mass spectrometry. I gratefully acknowledge all the members of my committee who have given their time to read this manuscript and who have also offered valuable advice during my graduate career at Texas A&M University. I am especially indebted to my wife Jian, who has continually offered her love, support, and guidance with her remarkable intelligence and most respectable perseverance in playing the role as a weekday single mother and a scientist. I'll never thank her enough for helping me realize this part of my American dream, completing studies with a Ph.D. degree in the United States. Best regards to all members of Dr. Russell's research group for their friendship. I gratefully acknowledge Drs. Lloyd Sumner and Barbara Wolf who provided me with one of the most comfortable working places I have ever had, and Walt Parker who helped me with instrumentation and valuable advice. In addition, I wish to thank Dr. Shuqiang Niu for his help with Gaussian calculations, the results of which are partially presented in Chapter V. Many thanks for financial assistance from the Department of Energy and Office of Basic Science whose support made this research possible.